intestinal obstruction, Hemic/Lymphatic: anemia, hypochromic anemia, hypervolemia, Metabolic/Nutritional: peripheral edema, hypoxia, Nervous System: insomnia, agitation, delirium, confusion, dizziness, seizure, nervousness, paresthesia, hallucinations, It kills bacteria that are resistant to other antibiotics. The most common adverse events occurring in greater than 5% of the patients were: Adverse events with an incidence of greater than 1%, and not listed above, include: For patients with varying degrees of renal impairment, the incidence of heart However severe cases of pneumonia require medical attention especially viral pneumonia. Confusion. Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locater Tool Including 24 Hour, Pharmacies. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease. Meropenem may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. 6 Several studies have indicated that the most important factor governing the neurotoxicity of a carbapenem is the concentration achieved in the brain tissue. Nausea and vomiting. Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures. Adverse Reactions. Upset stomach , headache , nausea , vomiting , constipation , or diarrhea may also occur. Bacteria cannot survive without a cell wall. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating drugs a-z list Meropenem can also affect your neurological (brain) function, which can cause dizziness, fainting, or seizures. If inflammation affects both lungs, the infection is termed double pneumonia. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Serious reactions rarely may occur such as: Serious hypersensitivity (allergic) reactions may occur. Terms of Use. Amropenem (500 mg) 500mg - 1 Vial Injection (Meropenem) drug information. What is meningitis and what causes it? What are the important side effects of Merrem IV (meropenem injection)? dehydrogenase (LDH), and bilirubin, Hematologic: increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased You are encouraged to report negative side effects of prescription drugs to the FDA. seizure, nervousness, paresthesia, hallucinations, somnolence, anxiety, Pneumonia may be contagious for 2-14 days. Side Effects Swelling, redness, pain, or soreness at the injection site may occur. In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. species. fainting. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies. bradycardia, hypotension, syncope, Digestive System: oral moniliasis, anorexia, cholestatic jaundice/jaundice, flatulence, ileus, hepatic failure, dyspepsia, valproic acid's glucuronide metabolite (VPA-g) back to valproic acid, thus Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). E. coli spreads from person to person via contaminated food or Safe and effective use of Merrem IV is not established in pregnant females. © Merrem IV Patient Information is supplied by Cerner Multum, Inc. and Merrem IV Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. failure, kidney failure, seizure and shock reported with Merrem IV, increased in The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with It is unknown if Merrem IV enters breast milk. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. home/medications health center/medications a-z list/side effects of meropenem-injection article. patients with moderately severe renal impairment (creatinine clearance 10 to 26 Merrem IV prevents bacteria from forming the walls that surround them. Adverse effects. 1. By continuing to browse this site you are agreeing to our use of cookies. Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. Latest Infectious Disease News Ticks Jumping From Dogs to Humans Upset stomach, headache, nausea, vomiting, constipation, or diarrhea may also occur. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). When taking Merrem (meropenem), you might experience stiff muscles or abnormal muscle movements. For patients with varying degrees of renal impairment, the incidence of heart failure, kidney failure, seizure and shock reported with MERREM IV, increased in patients with moderately severe renal impairment (creatinine clearance 10 to 26 mL/min) [see DOSAGE AND ADMINISTRATION,WARNINGS AND PRECAUTIONS, Use In Specific Populations and Use in pregnancy appears to be safe. Merrem IV. Merrem IV is effective against susceptible strains of E. coli, H. influenzae, K. pneumoniae, N. meningitidis, P. aeruginosa, and many other bacteria. It is administered intravenously. The adverse reactions seen in these patients that were reported and their rates of occurrence are as follows: Adverse Laboratory Changes in Pediatric Patients. Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Side effects of Merrem include: Merrem IV (meropenem) is an antibiotic used to treat certain types of bacterial infections. The following adverse reactions have been identified during post-approval use of MERREM IV. Meropenem was administered to treat Escherichia coli for 3 days through an IV in hospital - noticed loosening of stools gaseous stomach and some headaches - but … Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. It is administered intravenously. Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. Side effects of Merrem include: nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. MERREM IV. Tell your doctor or nurse right away if you or your child have itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine. Laboratory changes seen in the pediatric studies, including the meningitis studies, were similar to those reported in the adult studies. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. During clinical investigations, 2904 immunocompetent adult patients were treated for non-CNS infections with Merrem IV (500 mg or 1 gram every 8 hours). Get our free fact sheet. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Our Merrem IV Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Merrem (meropenem) is available as a generic. The study was open-label, uncontrolled, 98% of the infants received concomitant medications, and the majority of adverse events were reported in neonates less than 32 weeks gestational age and critically ill at baseline, making it difficult to assess the relationship of the adverse events to {{configCtrl2.info.metaDescription}} This site uses cookies. Antibiotics treat E. coli infection. What are the possible side effects of meropenem? Merrem (meropenem) may make you feel weak or confused. Diarrhea 4. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Safe and effective use of Merrem IV is not established in pregnant females. Below is a summary of known side effects for MERREM IV. Probenecid (Benemid) may increase levels of meropenem by reducing its elimination through the kidneys. Merrem IV is necessary, then supplemental anti-convulsant therapy should be If it affects one lung, it is termed single pneumonia. Skin reactions. Nausea 6. mL/min). Complicated Skin and Skin Structure Infections Shortness of breath. It’s good at treating severe and complicated bacterial infections. hemoperitoneum (0.2%). See additional information. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. If experienced, these tend to have a Severe expression 1. Worldwide post-marketing adverse reactions not otherwise listed in the Adverse Reactions from Clinical Trials section of this prescribing information and reported as possibly, probably, or definitely drug related are listed within each body system in order of decreasing severity. In the seriously ill patient population, it was not possible to determine the relationship between observed adverse events and therapy with Merrem IV. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to MERREM IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Visit the FDA MedWatch website or call 1-800-FDA-1088. E. coli can cause urinary tract and bladder infections, or lead to sepsis. hematocrit, decreased white blood cell (WBC), shortened prothrombin time and shortened partial thromboplastin time, Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These may be encountered; Pain at the site of injection. The meropenem group had a statistically higher number of patients with transient elevation of liver enzymes. chills. MERREM IV was studied in 321 pediatric patients (3 months to less than 17 years of age) with meningitis at a dosage of 40 mg/kg every 8 hours. Most people who take Merrem (meropenem) usually have few side effects. greater than 0.1% of the patients are listed below within each body system in order of decreasing frequency: Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, Systemic adverse events that were reported with MERREM IV occurring in greater than 1.0% of the patients were diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea (1.3%), shock (1.2%), and pruritus (1.2%). Infection is spread generally through contaminated food or drink. The following are discussed in greater detail in other sections of labeling: Because clinical trials are conducted under widely varying conditions, adverse reactions rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. There are several subtypes of the E. coli Risk of Breakthrough Seizures Due to Drug Interaction with Valproic Acid. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. Probenecid may increase levels of Merrem IV by reducing its elimination through the kidneys. What drugs interact with Merrem IV (meropenem injection)? CLINICAL PHARMACOLOGY]. Description: Meropenem is a β-lactam antibiotic.It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Black or tarry stools. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Merrem IV (meropenem injection) side effects list for healthcare professionals. Body as a Whole: pain, abdominal pain, chest pain, fever, back pain, abdominal enlargement, chills, pelvic pain, Cardiovascular: heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, There are many types of E. coli (Escherichia coli). In case of a severe side effect or reaction, call the doctor, nurse or pharmacist at 595-3300. Merrem IV (meropenem injection) is a carbapenem antibiotic used to treat a variety of bacteria. cold, clammy skin. Meningitis is an inflammation of the membrane (meninges) surrounding the brain and spinal cord and is characterized by an abnormal number of white blood cells in the cerebrospinal fluid. leukocytosis, hypokalemia, Renal: increased creatinine and increased blood urea nitrogen (BUN). Abdominal pain. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse events reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: Pediatric Patients with Bacterial Meningitis. water. Transiently elevated liver enzymes were the most common side-effect. The types of systemic and local adverse events seen in these patients are similar to the adults, with the most common adverse reactions reported as possibly, probably, or definitely related to Merrem IV and their rates of occurrence as follows: In the meningitis studies, the rates of seizure activity during therapy were comparable between patients with no CNS abnormalities who received meropenem and those who received comparator agents (either cefotaxime or ceftriaxone). Safe and effective use of Merrem IV is not established in pregnant females. Consult your doctor before breastfeeding. Meningitis is inflammation of the membranes that cover the spinal cord and brain. Meropenem Side Effects Swelling, redness, pain, or soreness at the injection site may occur. Symptoms include severe abdominal pain and bloody diarrhea. Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. Although not all of these side effects may occur, if they do occur they may need medical attention. MERREM IV. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection. considered. Merrem is used in the treatment of infections of the abdomen, such as appendicitis and peritonitis, bacterial meningitis (infection of the lining of the brain), and skin infections. Reconstitution procedure. Pneumonia can be deadly. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment) hives. Increased levels of meropenem in the body could increase side effects like nausea, vomiting, and headache. Read the entire FDA prescribing information for Merrem IV (Meropenem). In a study of complicated skin and skin structure infections, the adverse reactions were similar to those listed above. If administration of Common side effects of Merrem IV include injection site pain and inflammation, rash, constipation, diarrhea, nausea, vomiting, and headache. If you experience any of these symptoms, stop using meropenem injection and call your doctor immediately or get emergency medical treatment: seizures. diarrhea (4.8%), nausea/vomiting (3.6%), headache (2.3%), rash (1.9%), sepsis (1.6%), constipation (1.4%), apnea Although the mechanism of this interaction is unknown, data from in vitro (1.3%), shock (1.2%), and pruritus (1.2%). The following adverse reaction frequencies were derived from the clinical trials in the 2904 patients treated with In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Blood And Lymphatic System Disorders: agranulocytosis, neutropenia, and leukopenia; a positive direct or indirect Coombs test, and hemolytic anemia. In the Merrem IV treated group, 12/15 patients with seizures had late onset seizures (defined as occurring on day 3 or later) versus 7/20 in the comparator arm. Merrem IV was studied in 200 neonates and infants less than 3 months of age. Adverse laboratory changes that were reported and occurring in greater than 0.2% of the patients were as follows: Hepatic: increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, lactate
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